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• Hoda, DMG are TMG are on the same methylating chain. TMG just has 1 more methyl donor. Some kids do not need that extra methyl donor, some do. Our doctor has always said that he likes to start with DMG first. If the child responds well, than TMG might have even better results.
• Dimethylglycine, also known as DMG, is a natural substance found in both plant and animal cells, and is derived from the amino acid glycine (see reference 1 under Clinical Summary para 1). As a supplement, it is purported to offer a number of health benefits, from enhancing physical performance to.

Some children clearly respond better to TMG, and some to DMG, and some to the two together. For TMG, we use doses of 175 mg to start, and may move to doses as high as 1000 mg per day with further benefit. One good study used a TMG dose of 2000 mg per day without problem in any of the children.

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Millions of Americans take dietary supplements for a variety of purposes, including general health, athletic performance and as alternative therapy for an illness. Dimethylglycine, a derivative of the amino acid glycine, is a less commonly known substance available as a supplement. It has antioxidant properties. People take DMG as a supplement for a number of purported benefits; however, clinical data to support most claims are lacking. Talk to your doctor before taking supplements of any kind, including DMG.

Unraveling DMG

DMG is produced as a result of metabolizing choline, an amino acid that plays a role in cell signaling, nerve transmission and fat metabolism. DMG is found naturally in certain foods like beans, cereal grains and liver. It appears that DMG plays a role in producing glutathione during fetal development, according to the Memorial Sloan-Kettering Cancer Center. Glutathione is your body's primary antioxidant.

DMG Uses

Some people use DMG for antioxidant benefits. Antioxidants neutralize unstable atoms called free radicals, which can cause oxidative damage. This occurs when the body has more free radicals than it can handle at any given time. DMG also increases oxygenation at the cellular level, which may be why some people use it to enhance athletic performance. DMG has been used to boost the immune system, and to treat autism and chronic fatigue syndrome.

Supporting Clinical Data

Very few DMG studies exist and those that do fail to validate claims for most uses. There is no evidence that DMG improves athletic performance or chronic fatigue. Dagger dnd dmg. Studies to support its use for autism have been mixed. DMG does provide cellular protection against formaldehyde, according to a study published in the 2009 edition of 'The Journal of Biological Chemistry.' Formaldehyde is a toxic substance naturally present in the environment, and it results from certain metabolic processes.

Points to Consider

At the very least, DMG appears to provide antioxidant benefits, but you can get antioxidants from eating a diet rich in fruits and vegetables. A recommended dose has not been established, so follow the manufacturer's instructions. DMG is non-toxic and no adverse side effects have been reported, according to the Memorial Sloan-Kettering Cancer Center. Discontinue use if you experience unwanted effects that you suspect are related to DMG.

About the Author

Janet Renee is a clinical dietitian with a special interest in weight management, sports dietetics, medical nutrition therapy and diet trends. She earned her Master of Science in nutrition from the University of Chicago and has contributed to health and wellness magazines, including Prevention, Self, Shape and Cooking Light.

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Tmg Health Benefits

Tmg Supplement Safety

Dimethylglycine, also known as DMG, is a natural substance found in both plant and animal cells, and is derived from the amino acid glycine (see reference 1 under Clinical Summary para 1). As a supplement, it is purported to offer a number of health benefits, from enhancing physical performance to improving behavior in children with autism and attention deficit disorder. However, the evidence to support these claims is lacking, according to the Memorial Sloan Kettering Cancer Center (see reference 1 under Mechanism of Action).

How DMG Works

The body produces DMG in the cells by breaking down choline (see reference 1 under Clinical Summary). In the body, it acts as an antioxidant and improves oxygenation of the cells (see reference 1 under Clinical Summary). The thought is that taking DMG as a supplement may further enhance oxygenation, which improves athletic performance (see reference 1 under Clinical Summary). It is also thought to act as a neurological stimulator, which is why it has gained popularity in the autism community (see reference 1 under Clinical Summary). According to an October 2009 review article on the use of complementary medicine in autism published in 'Child and Adolescent Psychiatric Clinics,' the two clinical trials testing the use of DMG on children with autism showed no positive effect or improvement in behavior (see reference 2 under DMG).

Safety Concerns

DMG is considered a safe and non-toxic substance, according to MSKCC (see reference 1 under Clinical Summary). If you're supplementing your diet with DMG, be sure to inform your doctor to monitor for any potential side effects or interactions. Additionally, while it's safe to take DMG, do not rely on it as a cure or treatment for any illness.